Impumelelo ephambili yezenzululwazi kwinoveli yobuchwephesha bokungasebenzi kakuhle kwetekhnoloji, ephuhliswe yinkampani yemathiriyeli entsha ese-Heilongjiang, eTshayina, yapapashwa ngokusesikweni kwijenali yezemfundo yamazwe ngamazwe i-Nature ekuqaleni kukaNovemba ka-2025. Inconywa njengenkqubela phambili yodidi lwehlabathi kwi-synthesis yamachiza kunye ne-R&D, olu tshintsho lufumene ingqwalasela ebanzi malunga nokubanakho ukuhlengahlengisa iimodyuli ezininzi zemodyuli.
Eyona mpumelelo ingundoqo ilele ekuphuhliseni isicwangciso sokususa ngokuthe ngqo esixoxwe yi-N-nitroamine. Le ndlela yobuvulindlela ibonelela ngendlela entsha yokuguqulwa okuchanekileyo kwee-heterocyclic compounds kunye ne-aniline derivatives-iziseko zokwakha eziphambili ekuphuhlisweni kweziyobisi kunye ne-fine chemical synthesis. Ngokungafaniyo neendlela zendabuko zokuchithwa kwe-deamination ezihlala zixhomekeke kwi-intermediates engazinzanga okanye iimeko zokusabela ezinzima, iteknoloji ye-N-nitroamine-mediated inika i-paradigm shift ekusebenzeni kunye nokuguquguquka.
Izibonelelo ezintathu ezibalaseleyo zichaza le ndlela: indawo yonke, ukusebenza kakuhle okuphezulu, kunye nokulula kokusebenza. Ibonisa ukusetyenziswa okubanzi kuluhlu olubanzi lweeamolekyu ekujoliswe kuzo, ukuphelisa imida yeendlela eziqhelekileyo ezithintelwe yi-substrate structure okanye isikhundla seqela le-amino. Ukusabela kuqhubeka phantsi kweemeko ezithambileyo, ukuphepha imfuno yezinto ezinetyhefu okanye ubushushu obugqithisileyo / ulawulo loxinzelelo, olunciphisa kakhulu umngcipheko wokhuseleko kunye neempembelelo zokusingqongileyo. Okubaluleke kakhulu, iteknoloji igqibe ngempumelelo ukuqinisekiswa kwemveliso ye-kilogram-scale pilot, ebonisa ukuba nokwenzeka kwayo kwisicelo esikhulu soshishino kunye nokubeka isiseko esiluqilima sokuthengisa.
Ixabiso lokusetyenziswa kolu tshintsho ludlulela ngaphaya kwamayeza. Kulindeleke ukuba kufumaneke ukwamkelwa ngokubanzi kubunjineli bemichiza, izixhobo ezihambele phambili, kunye nokuhlanganiswa kwezibulali zinambuzane. Ekuphuhlisweni kweziyobisi, kuya kulungelelanisa ukuveliswa kwezinto eziphambili, ukukhawulezisa inkqubo ye-R & D yeziyobisi ezincinci ze-molecule ezifana ne-anticancer agents kunye neyeza ze-neurological. Kumacandelo eekhemikhali kunye nezinto eziphathekayo, ivumela ukuhlanganiswa okuluhlaza kunye neendleko eziphezulu zeekhemikhali ezikhethekileyo kunye nezinto zokusebenza. Kwimveliso yezitshabalalisi, inika indlela ezinzileyo yokuvelisa abaphakathi abasebenza ngokuphezulu ngelixa ithobela imithetho engqongqo yokusingqongileyo.
Le mpumelelo ayijonganga kuphela imiceli mngeni ekudala ikho kuhlengahlengiso lwemolekyuli kodwa yomeleza nesikhundla seTshayina ekuvelisweni kwemveliso yeekhemikhali. Njengoko ushishino luqhubela phambili, itekhnoloji ikulungele ukuqhuba iinzuzo ezisebenzayo kunye nokunciphisa iindleko kuwo wonke amacandelo amaninzi, ephawula inyathelo elibalulekileyo eliya phambili kutshintsho lwehlabathi olubhekiselele kwiindlela zokuvelisa eziluhlaza nezizinzileyo.
Ixesha lokuposa: Nov-14-2025