Itekhnoloji yoHlelo lweMolekyuli iguqula inkqubo yeXesha Elidala, iTekhnoloji yeAmine enevumba elimnandi yeDeamination Technology yenza iNguqu yeShishini

Uqhankqalazo olungundoqo

Ngomhla wama-28 ka-Okthobha, itekhnoloji ye-deamination functionalization ethe ngqo ye-amines enuka kamnandi ephuhliswe liqela likaZhang Xiaheng elisuka kwi-Hangzhou Institute for Advanced Study, iYunivesithi yaseTshayina yeSayensi yeSayensi (HIAS, UCAS) yapapashwa kwiNdalo. Le teknoloji ixazulula imingeni yokhuseleko kunye neendleko eziye zaphazamisa ishishini lemichiza iminyaka eyi-140.

Iimbalasane zobuGcisa

I-1.Ilahla inkqubo yetyuwa ye-diazonium yendabuko (ilungele ukuqhuma kunye nokungcola okuphezulu), ukufezekisa ukuguqulwa kwebhondi ye-CN esebenzayo ngokusebenzisa i-N-nitroamine intermediates.
I-2.Ifuna akukho catalysts zetsimbi, ukunciphisa iindleko zokuvelisa nge-40% -50%, kwaye igqibe ukuqinisekiswa kwe-kilogram-scale.
3.Isebenza phantse kuwo onke amayeza e-heteroaromatic amines kunye ne-aniline derivatives, ngaphandle kokuthintelwa yindawo yeqela le-amino.

Impembelelo yoShishino

I-1.Ishishini le-Pharmaceutical: Njengoko i-skeleton engundoqo ye-70% yamachiza amancinci e-molecule, i-synthesis ye-intermediates yamachiza e-anti-cancer kunye ne-antidepressants iba ikhuselekile kwaye inoqoqosho ngakumbi. Amashishini afana ne-Baicheng Pharmaceutical kulindeleke ukuba abone ukuthotywa kweendleko nge-40% -50%.
I-2.Ishishini leDyestuff: Amashishini aphambili afana neZhejiang Longsheng, abambe i-25% yesabelo semarike kwi-amines enuka kamnandi, asombulule umngcipheko woqhushumbo olude luthintele ukwandiswa kwamandla.
3.Ushishino lwezitshabalalisi: Amashishini aquka iYangnong Chemical aya kufumana ukuhla okubalulekileyo kweendleko zezibulali zinambuzane.
I-4.Izixhobo ze-elektroniki: Ikhuthaza ukuhlanganiswa okuluhlaza kwezinto ezikhethekileyo zokusebenza.

I-Capital Market Reaction

Ngomhla wesi-3 kuNovemba, icandelo leekhemikhali liye laqina ngokuchasene nentsingiselo yemarike, kunye necandelo le-amine elivumba likhokelela kwiinzuzo kunye neengcamango ezinxulumene nezabelo ezibonisa amandla apheleleyo.