I-Glutaraldehyde Technology Frontier: Ukuphumelela kwiTekhnoloji ye-Anti-Calcification

Kwintsimi ye-cardiovascular implants, i-glutaraldehyde sele isetyenziselwa ukuphatha izicubu zezilwanyana (ezifana ne-bovine pericardium) ukuveliswa kwee-valve ze-bioprosthetic. Nangona kunjalo, amaqela ashiyekileyo e-aldehyde akhululekile kwiinkqubo zendabuko angakhokelela kwi-post-implantation calcification, ebeka esichengeni ukuqina kwexesha elide kweemveliso.

Ukujongana nalo mngeni, uphononongo lwamva nje olupapashwe ngo-Epreli ka-2025 lwazisa isisombululo sonyango esichasene ne-calcification (igama lemveliso: Periborn), ukufikelela kwinkqubela phambili ephawulekayo.

1.Uphuculo olungundoqo lobuchwephesha:

Esi sisombululo sazisa uninzi lophuculo oluphambili kwinkqubo yemveli yokudibanisa i-glutaraldehyde:

I-Organic Solvent Cross-Linking:
I-Glutaraldehyde cross-linking yenziwa kwi-solvent ye-organic ehlanganiswe ne-75% ye-ethanol + i-5% ye-octanol. Le ndlela inceda ngokufanelekileyo ukususa i-phospholipids yezicubu ngexesha le-cross-linking-phospholipids ibe yindawo yokuqala ye-nucleation yokubala.

Ummeli wokuzalisa isithuba:

Emva kwe-cross-linking, i-polyethylene glycol (PEG) isetyenziswe njenge-ejenti yokuzalisa indawo, ingena ngaphakathi kwezithuba phakathi kwe-collagen fibers. Oku zombini zikhusela iindawo ze-nucleation ze-crystals ze-hydroxyapatite kwaye zivimbela ukungena kwe-calcium kunye ne-phospholipids kwi-plasma yokusingatha.

Ukutywinwa kwendawo:

Ekugqibeleni, unyango nge-glycine lunciphisa intsalela, amaqela e-aldehyde asebenzayo asebenzayo, ngaloo ndlela asuse enye into ephambili eyenza ukubalwa kunye ne-cytotoxicity.

2.Iziphumo zeklinikhi eziBalaseleyo:

Le teknoloji isetyenziswe kwi-scaffold yenkomo ye-pericardial ebizwa ngokuba yi "Periborn." Uphononongo olulandelwayo lweklinikhi olubandakanya izigulane ze-352 kwiminyaka eyi-9 lubonise inkululeko ekusebenzeni kwakhona ngenxa yemicimbi enxulumene nemveliso ephezulu njenge-95.4%, eqinisekisa ukusebenza kwesi sicwangciso esitsha sokulwa nokubala kunye nokuqina kwayo okungaqhelekanga kwexesha elide.

Ukubaluleka Kolu Phulo:

Ayijonganga kuphela umngeni osele umile kwintsimi yeevalvu ze-bioprosthetic, ukwandisa ixesha lokuphila kwemveliso, kodwa iphinda ifake ubutsha obutsha ekusebenziseni i-glutaraldehyde kwizinto eziphezulu ze-biomedical.