Kwicandelo le-cardiovascular implants, i-glutaraldehyde ibisoloko isetyenziswa ukunyanga izicubu zezilwanyana (ezifana ne-bovine pericardium) ukuvelisa ii-valve ze-bioprosthetic. Nangona kunjalo, amaqela e-aldehyde asimahla asele avela kwiinkqubo zemveli anokukhokelela kwi-calcification emva kokufakelwa, okubeka emngciphekweni ukuqina kwexesha elide kwemveliso.
Ukujongana nalo mceli mngeni, uphando lwamva nje olupapashwe ngo-Epreli 2025 lwazisa isisombululo esitsha sonyango oluchasene ne-calcification (igama lemveliso: iPeriborn), olufezekisa inkqubela phambili emangalisayo.
1. Uphuculo oluPhambili lweTekhnoloji:
Esi sisombululo sazisa uphuculo oluphambili kwinkqubo yesiqhelo yokudibanisa i-glutaraldehyde:
Ukudibanisa i-Organic Solvent Cross-Linking:
I-Glutaraldehyde cross-linking yenziwa kwi-organic solvent eyenziwe yi-75% ethanol + 5% octanol. Le ndlela inceda ekususeni ngempumelelo ii-tissue phospholipids ngexesha le-cross-linking—ii-phospholipids ziziindawo eziphambili ze-nucleation ze-calcification.
Iarhente yokuzalisa isithuba:
Emva kokudibanisa i-cross-linking, i-polyethylene glycol (PEG) isetyenziswa njenge-arhente yokugcwalisa isithuba, ingena kwizikhewu phakathi kwee-collagen fibers. Oku kukhusela iindawo ze-nucleation zeekristale ze-hydroxyapatite kwaye kuthintela ukungena kwe-calcium kunye ne-phospholipids kwi-plasma yomninimzi.
Ukutywinwa kwesiphelo:
Okokugqibela, unyango nge-glycine luphelisa amaqela asele e-aldehyde akhululekileyo, ngaloo ndlela lususa enye into ephambili ebangela i-calcification kunye ne-cytotoxicity.
2. Iziphumo zeKliniki eziBalaseleyo:
Le teknoloji isetyenzisiwe kwi-scaffold ye-pericardial yenkomo ebizwa ngokuba yi-“Periborn.” Uphononongo olulandelayo lweklinikhi olugubungela izigulana ezingama-352 kwiminyaka engaphezu kwe-9 lubonise ukukhululeka ekusebenzeni kwakhona ngenxa yeengxaki ezinxulumene nemveliso ezifikelela kwi-95.4%, nto leyo eqinisekisa ukusebenza kakuhle kwale ndlela intsha yokulwa ne-calcification kunye nokuqina kwayo okumangalisayo kwexesha elide.
Ukubaluleka Kolu Phambuko:
Ayijongani nje kuphela nomngeni wexesha elide kwicandelo leevalvu ze-bioprosthetic, yandisa ubomi bemveliso, kodwa ikwafaka amandla amatsha ekusebenziseni i-glutaraldehyde kwizixhobo ze-biomedical eziphezulu.
Ixesha leposi: Okthobha-28-2025