Indlela yokuhlalutya inoveli, ebonakaliswe ngokuchaneka okuphezulu kunye novelwano olunamandla, luphuhliswe ngempumelelo ukuzimisela kwe-4,4'-methylene-bis- (2-chloroaniline), eyaziwa ngokuba yi "MOCA," kumchamo womntu. Kubalulekile ukuqaphela ukuba i-MOCA yi-carcinogen ebhalwe kakuhle, kunye nobungqina be-toxicological obusekiweyo obuqinisekisa ukuba i-carcinogenicity yayo kwizilwanyana zaselabhoratri ezifana neempuku, iimpuku kunye nezinja.
Ngaphambi kokusebenzisa le ndlela esanda kuphuhliswa kwimimiselo yomsebenzi wehlabathi lokwenene, iqela lophando laqala ukwenza uphando lwexesha elifutshane lokuqala usebenzisa iigundane. Injongo ephambili yolu phononongo lwangaphambili yayikukubona kunye nokucacisa izinto ezithile eziphambili ezihambelana nokukhutshwa komchamo we-MOCA kwimodeli yezilwanyana-kubandakanywa nemiba efana nesantya sokukhupha, i-metabolic pathways, kunye nefestile yexesha lamanqanaba anokubonwa-ukubeka isiseko esiluqilima sesayensi kwisicelo esilandelayo sendlela kwiisampuli zabantu.
Emva kokugqitywa kunye nokuqinisekiswa kophononongo lwangaphambili, le ndlela yokukhangela esekwe kumchamo yasetyenziswa ngokusesikweni ukuvavanya ubungakanani bokuchayeka emsebenzini kwi-MOCA phakathi kwabasebenzi kumashishini amashishini aseFransi. Umda wovavanyo wagubungela iindidi ezimbini eziphambili zezehlo zokusebenza ezinxulumene ngokusondeleyo ne-MOCA: enye yayiyinkqubo yokuveliswa kweshishini le-MOCA ngokwayo, kwaye enye yayikukusetyenziswa kwe-MOCA njenge-arhente yokunyanga kwimveliso ye-polyurethane elastomers, imeko yesicelo esiqhelekileyo kwimichiza kunye nemveliso yempahla.
Ngovavanyo olukhulu lweesampuli zomchamo eziqokelelwe kubasebenzi kule meko, iqela lophando lifumene ukuba amanqanaba okukhutshwa komchamo we-MOCA abonise uluhlu olubanzi lokuhluka. Ngokukodwa, i-excretion concentrations isuka kumanqanaba angabonakaliyo-achazwe ngaphantsi kwe-0.5 microgram nganye ilitha-ubuninzi be-1,600 micrograms ilitha. Ukongezelela, xa i-metabolites ye-N-acetyl ye-MOCA ikhona kwiisampuli zomchamo, ukugxininiswa kwazo kwakuhlala ngokuqhubekayo kwaye kuphantsi kakhulu kunogxininiso lwe-compound yomzali (MOCA) kwiisampuli ezifanayo, ebonisa ukuba i-MOCA ngokwayo iyona ndlela ephambili ekhutshwe kumchamo kunye nesalathisi esithembekileyo sokuvezwa.
Lilonke, iziphumo ezifunyenwe kolu vavanyo lubanzi lokuvezwa komsebenzi zibonakala zibonisa ngokufanelekileyo kwaye ngokuchanekileyo amanqanaba okuvezwa kwe-MOCA ewonke abasebenzi abaphononongiweyo, njengoko amanqanaba okukhutshelwa afunyenweyo ayenxibelelene ngokusondeleyo nobume bomsebenzi wabo, ixesha lokuvezwa, kunye neemeko zokusingqongileyo zokusebenza. Ngapha koko, uqwalaselo olubalulekileyo olusuka kuphononongo yayikukuba emva kokuba ukumiselwa kohlalutyo kugqitywe kwaye kwaphunyezwa amanyathelo othintelo ekujoliswe kuwo kwiindawo zokusebenzela-ezifana nokuphucula iinkqubo zokungenisa umoya, ukuphuculwa kokusetyenziswa kwezixhobo zokukhusela (PPE), okanye ukuphucula ukusebenza kwenkqubo-amanqanaba okukhutshwa komchamo we-MOCA kubasebenzi abachaphazelekayo bahlala bebonisa ukuhla okucacileyo kunye nokuthintela okubonakalayo ekunciphiseni ukungenelela okusebenzayo. ukuvezwa kwi-MOCA.
Ixesha lokuposa: Oct-11-2025