Uvavanyo lokuvezwa emsebenzini kwi-4,4′-methylene-bis-(2-chloroaniline) “MOCA” ngendlela entsha ebucayi yokujonga izinto eziphilayo

Indlela entsha yokuhlalutya, ephawulwa ngokuchaneka okuphezulu kunye nobuntununtunu obuqinileyo, iphuhliswe ngempumelelo ukuze kufunyanwe i-4,4′-methylene-bis-(2-chloroaniline), eyaziwa ngokuba yi-"MOCA," kumchamo womntu. Kubalulekile ukuqaphela ukuba i-MOCA yi-carcinogen ebhalwe kakuhle, enobungqina obuyityhefu obuqinisekisa ukuba i-carcinogen yayo kwizilwanyana zaselabhoratri ezifana neempuku, iimpuku, kunye nezinja.

Ngaphambi kokusebenzisa le ndlela intsha iphuhlisiwe kwiindawo zomsebenzi zokwenyani, iqela lophando liqale lenza uphando lokuqala lwexesha elifutshane lisebenzisa iimpuku. Injongo ephambili yolu phononongo lwangaphambi kweklinikhi yayikukuchonga nokucacisa iimpawu ezithile ezibalulekileyo ezinxulumene nokukhutshwa kwe-MOCA kumchamo kwimodeli yezilwanyana—kuquka iinkalo ezifana nesantya sokukhutshwa, iindlela zemetabolism, kunye nexesha lamanqanaba anokubonwa—ukubeka isiseko esiqinileyo sesayensi sokusetyenziswa okulandelayo kwendlela kwiisampuli zabantu.

Emva kokugqitywa nokuqinisekiswa kophando lwangaphambi kweklinikhi, le ndlela yokufumanisa umchamo yasetyenziswa ngokusesikweni ukuvavanya ubungakanani bokuchaphazeleka emsebenzini kwi-MOCA phakathi kwabasebenzi kumashishini emizi-mveliso aseFransi. Ububanzi bophando bugubungele iintlobo ezimbini eziphambili zeemeko zomsebenzi ezinxulumene kakhulu ne-MOCA: enye yayiyinkqubo yokuvelisa imveliso yemizi-mveliso ye-MOCA ngokwayo, kwaye enye yayikukusetyenziswa kwe-MOCA njengearhente yokunyanga ekwenzeni ii-polyurethane elastomers, imeko eqhelekileyo yokusetyenziswa kumashishini eekhemikhali nezinto.

Ngovavanyo olukhulu lweesampuli zomchamo eziqokelelwe kubasebenzi kwezi meko, iqela lophando lifumanise ukuba amanqanaba okukhupha umchamo we-MOCA abonise umahluko omkhulu. Ngokukodwa, amazinga okukhupha ayeqala kumanqanaba angabonakaliyo—achazwe njenge-0.5 microgram ngelitha—ukuya kuthi ga kwi-1,600 micrograms ngelitha. Ukongeza, xa i-N-acetyl metabolites ze-MOCA zazikho kwiisampuli zomchamo, amazinga azo ayephantsi rhoqo kwaye ehambelana kakhulu namazinga e-compound yomzali (MOCA) kwiisampuli ezifanayo, nto leyo ebonisa ukuba i-MOCA ngokwayo yindlela ephambili ekhutshwa ngayo kumchamo kwaye sisalathisi esithembekileyo sokuvezwa.

Ngokubanzi, iziphumo ezifunyenwe kolu vavanyo lukhulu lokuvezwa emsebenzini zibonakale zibonisa ngokufanelekileyo nangokuchanekileyo amanqanaba okuvezwa kwe-MOCA kubasebenzi abahlolisisiweyo, njengoko amanqanaba okukhutshwa afunyenweyo ayenxulumene kakhulu nohlobo lomsebenzi wabo, ixesha lokuvezwa, kunye neemeko zendawo yokusebenza. Ngaphezu koko, into ebalulekileyo efunyenwe kolu phononongo yayikukuba emva kokuba izigqibo zohlalutyo zigqityiwe kwaye amanyathelo okuthintela ajoliswe ekusetyenzisweni kwiindawo zokusebenza—njengokuphucula iinkqubo zokungenisa umoya, ukuphucula ukusetyenziswa kwezixhobo zokuzikhusela (PPE), okanye ukuphucula imisebenzi yenkqubo—amanqanaba okukhutshwa komchamo we-MOCA kubasebenzi abachaphazelekayo adla ngokubonisa ukwehla okucacileyo nokubalulekileyo, okubonisa ukusebenza kakuhle kwezi ndlela zokuthintela ekunciphiseni ukuvezwa kwe-MOCA emsebenzini.